New York City is in desperate need of heroes. It is ruled by fear and the all-powerful Ripper (William Fichtner), whose position as ruler of the underworld is completely unshakable until four amphibians with extraordinary abilities emerge from the city's sewers due to a failed genetic experiment.

Where Michelangelo, Donatello, Leonardo and Raphael are, the curious reporter April, played by Megan Fox, cannot be missing.